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Mubychem Group, established in 1976, is the pioneer manufacturer of Manganese Sulphate, Pharmaceutical Fragrances & Flavour Chemicals in India. Mubychem Group has manufacturing facilities spread across Western India. The group is a chemical exporter to almost every country and has a local representative in major business areas. |
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MSDS of Methylene Blue USP Methylthioninium Chloride BP Manufacturers
Methylene Blue USP Methylthioninium Chloride BP Methylene Blue Manufacturers
Chemical Formula: C16H18N3CIS
Molecular Weight: 319.85 gm / mole
Chemical Name: 3,7-bis(Dimethylamino)-phenazathionium chloride Tetramethylthionine chloride
CAS Registration: 61-73-4
C.I No.: 52015
Appearance: Dark Green Crystalline Powder
Assay (as is basis): 80 % - 85%
Assay (on dry basis): 98% -101%
Loss on drying: 10% -20%
Solubility: Clear Blue Solution
Ash content: 1% Max
Residual Solvent: Nil
Aluminium: 100 ppm Max
Cadmium: 1ppm Max
Chromium: 10ppm Max
Copper: 50ppm Max
Tin: 10 ppm Max
Iron: 100ppm Max
Manganese: 10ppm Max
Mercury: Nil
Molybdenum: 10ppm Max
Methylene Blue USP
Methylene Blue
C16H18ClN3S·3H2O 373.90
Phenothiazin-5-ium, 3,7-bis(dimethylamino)-,
chloride, trihydrate.
C.I. Basic Blue 9 trihydrate [7220-79-3]
Anhydrous
319.86 [61-73-4]
Identification: Infrared Absorption 197K .
Loss on drying— Dry it at 75 and at a
pressure not exceeding 5 mm of mercury for 4 hours: it loses between
8.0% and 18.0% of its weight.
Residue on ignition: not more than 1.2%.
Arsenic— Prepare the Test Preparation by mixing 0.375 g
with 10 mL of water in the arsine generator
flask. Add 15 mL of nitric acid and 5
mL of perchloric
acid, mix, and heat cautiously to the production of strong fumes of
perchloric acid. Cool, wash down the sides
of the flask with water, and again heat to strong fumes.
Again cool, wash down the sides of the flask, and
heat to fumes. Cool, dilute with water to 52 mL, and add 3
mL of hydrochloric
acid: the resulting solution meets the requirements of the test, the
addition of 20 mL of 7 N
sulfuric acid specified for Procedure being omitted. The
limit is 8 ppm.
Copper or zinc— Ignite 1.0 g in a porcelain crucible, using as
low a temperature as practicable, until all of the carbon is oxidized.
Cool the residue, add 15 mL of 2 N nitric acid, and boil for 5 minutes.
Filter the cooled solution, and wash any residue with 10
mL of water. To the combined filtrate and
washing add an excess of 6 N ammonium hydroxide,
and filter the solution into a 50 mL
volumetric flask. Wash the precipitate with small portions of water,
adding the washings to the filtrate, dilute
the solution with water to volume, and mix. To 25 mL of the solution add 10
mL of
hydrogen sulfide TS: no turbidity is produced within 5 minutes (absence of zinc).
Any dark color produced does not exceed that of a
control prepared by boiling a quantity of cupric sulfate, equivalent to
200 @g of copper, with 15 mL of 2 N nitric
acid for 5 minutes and by treating this solution as directed above,
beginning with “Filter the cooled solution” (0.02% of copper).
Chromatographic purity— Quantitatively dissolve an accurately
weighed quantity of Methylene Blue in
methanol to obtain a Test solution containing 1.0 mg per
mL Dissolve a suitable quantity of USP
Methylene Blue RS in methanol to obtain a
Standard solution having a concentration of 100 @g per
mL. Quantitatively dilute a portion of this
solution with methanol to obtain a Diluted standard solution having a concentration of 10 @g per
mL.
Apply 5 @L each of the Test solution, the Standard solution,
and the Diluted standard solution to a suitable thin-layer
chromatographic plate coated with a 0.25-mm layer of
octadecylsilanized chromatographic silica
gel. Allow the spots to dry, and develop the chromatogram in a
chromatographic chamber with a solvent system consisting of a mixture of
the upper layer separated from a well-shaken mixture of water, n-butanol,
and glacial acetic acid (100:80:20), until the solvent front has moved
about three-fourths of the length of the plate. Remove the plate from
the chamber, allow the solvent to evaporate, and visually locate the
spots on the plate: the RF value of the principal spot in the
chromatogram from the Test solution corresponds to that from the
Standard solution, and other spots, if present in the
chromatogram from the Test solution, consist of a secondary spot
that does not exceed in size or intensity, the principal spot obtained
from the Standard solution (10%), and not more than two
additional spots, neither of which exceeds in size or intensity the
principal spot from the Diluted standard solution (1%)Assay—
Transfer about 100 mg of Methylene Blue,
accurately weighed, to a 250-mL volumetric flask, dissolve in and dilute
with diluted alcohol to volume, and mix. Transfer 5.0
mL of this solution to a 100-mL volumetric
flask, dilute with diluted alcohol to volume, and mix. Transfer 5.0
mL of this solution to a 50-mL volumetric
flask, dilute with diluted alcohol to volume, and mix. This solution
contains about 2 @g per mL. Dissolve an
accurately weighed quantity of USP Methylene
Blue RS in diluted alcohol, and dilute quantitatively and stepwise
with diluted alcohol to obtain a Standard solution having a known
concentration of about 2 @g per mL.
Concomitantly determine the absorbance of
both solutions in 1-cm cells at the wavelength of maximum absorbance at
about 663 nm, with a suitable spectrophotometer, using diluted alcohol
as the blank. Calculate the quantity, in mg, of C16H18ClN3S in the
Methylene Blue taken by the formula:
in which C is the concentration, in @g per mL, of anhydrous methylene blue in the Standard solution; and AU and AS are the absorbance of the solution of Methylene Blue and the Standard solution, respectively.
Methylthioninium Chloride BP or Methylthioninium Chloride Ph. Eur is also offered.
IUPAC name is 3,7-Bis(dimethylamino)phenothiazin-5-ylium chloride or 3,7-bis(Dimethylamino)-phenothiazin-5-ium chloride
Methylene Blue USP Methylthioninium Chloride BP Manufacturers:
MUBY
CHEMICALS
S-8, SARIFA MANSION,
2ND FLANK ROAD, CHINCHBUNDER, MUMBAI 400009, INDIA
TEL: (OFFICE) 91-22-23770100,
23774610, 23726950, 23723564. FAX: 91-22-23728264.
E-mail: info@mubychem.com
USA & Canadian Customers may Call 773-829-5811; 312-450-3880
Copyright
and Usual Disclaimer is
Applicable
Last updated
April 07, 2012
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I shall pass through this world, but once. If therefore, there is any good that I can do, or if there is any favour that I can show to a fellow human being, let me do it now. Let me not defer or neglect it. For I shall not tread this way again.
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Muby Chemicals Old Spice: Manufacturing since more than Three Decades: |
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